Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetActivator of soluble guanylyl cyclase

General description

A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase. Inhibits platelet adhesion to collagen and acts as an antithrombotic agent. Reported to reduce HIF-1α levels and xenograft growth.

A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase. Inhibits platelet adhesion to collagen and acts as an antithrombotic agent.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Yeo, E.J., et al. 2003. J. Natl Cancer Inst.95, 516.Mulsch, A., et al. 1997. Br. J. Pharmacol. 120, 681.Teng, C.M., et al. 1997. Eur. J. Pharmacol. 320, 161.Wu, C.C., et al. 1997. Biochem. Biophys. Res. Commun. 231, 412.Wu, C.C., et al. 1995. Br. J. Pharmacol. 116, 1973.

Packaging

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)